3D structure is better conserved than sequence during evolution. Today's proteins reflect millions of years of evolution. Two conserved sequences similar structures Two similar structures conserved sequences ? There are cases of proteins with the same structure but no clear sequence similarity. Beta-alpha-beta unit Beta hairpin Helix hairpinĦ Fold: General structure composed of sets of Supersecondary structures Protein loops - variable regions Surface loops Hydrophobic coreĪssembly of secondary structures which are shared by many structures. Protein structure is more conserved than protein sequence, and more closely related to function.Ĥ Protein Structure Protein core - usually conserved. Each protein has a particular 3D structure that determines its function. Proteins are fundamental components of all living cells, performing a variety of biological tasks.
1 Protein Structure, Databases and Structural Alignment
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